Screening method for the identification of agents capable of activating CD4+CD25+ regulatory T-cells through interactions with the HIV-1 GP120 binding site on CD4

US10729742B2 · kind B2 · utility

Assignee

• Universitätsmedizin der Johannes Gutenberg-Universität Mainz · DE

Inventors

• Franz-Josef Schneider · Laupheim, DE
• Christian Becker · Ratingen, DE
• Tobias Bopp · Katzenelnbogen, DE
• Helmut Jonuleit · Ginsheim-Gustavsburg, DE
• Edgar Schmitt · Mainz, DE

Key dates

• Filing date: Oct 5, 2016
• Grant date: Aug 4, 2020
• Expiry date: Feb 28, 2037

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2333/7051
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates specific activation of a regulatory T cell via a specific CD4 epitope and uses thereof, e.g. for the treatment of an autoimmune disease or an allergy or asthma or graft rejection or tolerance induction.