Carrier-linked treprostinil prodrugs

US10729778B2 · kind B2 · utility

Assignee

• ASCENDIS PHARMA A/S · DK

Inventors

• Ulrich Hersel · Heidelberg, DE
• Harald Rau · Würzburg, DE
• Torben Lessmann · Neustadt an der Weinstraße, DE
• Nicola Bisek · Heidelberg, DE
• Guillaume Maitro · Mannheim, DE
• Kennett Sprogøe · Rudegård, DK
• Thomas Wegge · Heidelberg, DE
• Oliver Keil · Glienicke, DE
• Joachim Zettler · Heidelberg, DE

Key dates

• Filing date: Jan 27, 2017
• Grant date: Aug 4, 2020
• Expiry date: Jan 27, 2037

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P11/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Prodrugs or a pharmaceutically acceptable salt thereof which comprise a covalent treprostinil carrier conjugate, as well as their pharmaceutical composition, may be used as medicaments, especially for diseases or disorders which can be treated by treprostinil, such as pulmonary arterial hypertension (PAH).