Isotope purification method

US10729794B2 · kind B2 · utility

Assignee

• Bayer AS · NO

Inventors

• Janne Olsen FRENVIK · Oslo, NO
• Olav Ryan · Maridalen, NO

Key dates

• Filing date: Dec 29, 2016
• Grant date: Aug 4, 2020
• Expiry date: Dec 29, 2036

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61N2005/1021
• WIPO field: Chemical engineering
• WIPO sector: Chemistry

Abstract

The invention provides a method for the purification of 227 Th from a mixture comprising 227 Th and 223 Ra, said method comprising: i) preparing a first solution comprising a mixture of 227 Th and 223 Ra ions dissolved in a first aqueous buffer; ii) loading said first solution onto a separation material such as a strong cation exchange resin; iii) eluting 227 Th from the separation material, whereby to generate a second solution comprising 227 Th; iv) Optionally rinsing said separation material using a first aqueous washing medium; The invention additionally provides a method for forming a radio pharmaceutical comprising complexing the purified 227 Th, the pharmaceutical product and its use in treatment of disease such as cancer and a kit for generation of such a product.