Method for preparing chitosan/heparinized graphene oxide composite multilayer film on surface of medical magnesium alloy
US10729821B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | May 27, 2017 |
| Grant date | Aug 4, 2020 |
| Priority date | — |
| Expiry date | May 22, 2038 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L2420/08
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
A method for preparing a chitosan/heparinized graphene oxide composite multilayer film on the surface of a medical magnesium alloy comprises the following steps: firstly preparing negatively charged heparinized graphene oxide; then performing surface chemical treatment and self-assembly of 16-phosphonohexadecanoic acid molecules on the medical magnesium alloy; further covalently immobilizing chitosan on the surface of the magnesium alloy, thereby constructing a positively charged material surface; finally, alternately immersing the surface-modified magnesium alloy material in heparinized graphene oxide and a chitosan solution, and then fully adsorbing, and obtaining the chitosan/heparinized graphene oxide composite multilayer film after drying. The surface modification of the medical magnesium alloy by adopting the method of the present invention can significantly improve the corrosion resistance and biocompatibility of the magnesium alloy to lay a foundation for the application of the magnesium alloy in the field of implantable medical devices such as vascular stents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.