Thalidomide analogs and methods of use

US10730835B2 · kind B2 · utility

Assignees

• The United States of America, as represented by the Secretary, Health and Human Services · US
• The University Court of the University of Aberdeen · GB

Inventors

• Nigel H. Greig · Phoenix, US
• Weiming Luo · Timonium, US
• David Tweedie · Joppatowne, US
• Neil Vargesson · Aberdeen, GB
• Shaunna Beedie · Aberdeen, GB
• William D. Figg · Fairfax, US

Key dates

• Filing date: Sep 29, 2016
• Grant date: Aug 4, 2020
• Expiry date: Sep 29, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D499/80
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Thalidomide analogs and methods of using the thalidomide analogs are disclosed. Some embodiments of the disclosed compounds exhibit anti-angiogenic and/or anti-inflammatory activity. Certain embodiments of the disclosed compounds are non-teratogenic.