Patent · US Active

Polymorph of triaryldimethylpiperazine dihydrochloride and preparation method and application thereof

US10730851B2 · kind B2 · utility

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0References

17Claims

0Family size

Assignee

Yunnan Institute of Materia Medica · CN

Inventors

Jingkun Wang · Longchuan, CN
Zhaoyun Zhu · Longchuan, CN
He Song · Nanjing, CN
Min Sun · Shanghai, CN
Tao Cui · Longchuan, CN
Zeren Wang · Longchuan, CN
Zhi Yang · Kunming, CN
Min-Chieh Su · Taipei, TW
Hongbin Liu · Beijing, CN
Bing Shi · Redwood City, US
Yong Mao · Berkeley Heights, US
Huilang Liu · Kunming, CN
Zeqian Li · Kunming, CN
Chunmei Zhao · Kunming, CN
Mei Su · 林湖乡, CN
Fang Yuan · Ningbo City, CN
Tiancai Zhang · Kunming, CN
Yong Liu · Shanghai, CN
Kuanren Zhang · Kunming, CN
Yunlin Wei · Kunming, CN
Yuehai Shen · Kunming, CN

Key dates

Filing date	Nov 21, 2016
Grant date	Aug 4, 2020
Priority date	—
Expiry date	Nov 21, 2036

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07B2200/13
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The application discloses five polymorph forms B, P, F, J, O of (4-((R)-((2S,5R)-4-(3-fluorobenzyl)-(2,5-dimethylpiperazine-1-yl)(3-hydroxyphenyl)methyl)phenyl)(4-methylpiperidine-1-yl)methanone dihydrochloride, preparation methods thereof and application thereof in the manufacture of a medicament for preventing or treating a mood disorder or a disease related to a δ opioid receptor.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.