Lactam, cyclic urea and carbamate, and triazolone derivatives as potent and selective rock inhibitors
US10730858B2 · kind B2 · utility
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14Claims
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Key dates
| Filing date | Jul 6, 2017 |
| Grant date | Aug 4, 2020 |
| Priority date | — |
| Expiry date | Jul 6, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D495/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides compounds of Formula (I): Formula (I) or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.