Compound and use thereof and platinum complex and lipidosome thereof
US10730898B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Jan 13, 2017 |
| Grant date | Aug 4, 2020 |
| Priority date | — |
| Expiry date | Jan 13, 2037 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided are a platinum complex and a liposome thereof, and a use thereof. The platinum complex contains a carboxyl group having pH sensitivity, wherein in a comparatively low pH environment (such as in tumour tissues), the carboxyl group is liable to deprotonate, facilitating an improvement in the drug release inside tumour tissues and improving the therapeutic effect of drugs. In addition, the platinum complex can be well combined with the membrane materials of lipidosomes, so as to improve the encapsulation ratio and drug loading capacity of lipidosomes. Experiments indicate that the lipidosomes of the platinum complex can reduce the toxic and side effects of drugs and increase the therapeutic effect thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.