Patent · US Active

Composition and method for affecting the binding of antigen-binding polypeptides to antigens

US10730922B2 · kind B2 · utility

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5Claims

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Assignee

MILTENYI BIOTEC B.V. & CO. KG · DE

Inventors

Stefan Dubel · Dossenheim, DE
Sarah-Jane Kellmann · Gummersbach, DE
Holger Thie · Biberach, DE

Key dates

Filing date	Jul 14, 2017
Grant date	Aug 4, 2020
Priority date	—
Expiry date	Nov 30, 2037

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2319/03
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The present invention provides a composition comprising i) a polypeptide comprising calmodulin and two immunoglobulin superfamily domains, wherein said two immunoglobulin superfamily domains are linked via said calmodulin; ii) a calmodulin binding molecule; iii) ions binding to the Ca2+ binding site of calmodulin; wherein the binding of said calmodulin-binding molecule and of said ions to said Ca2+ binding site of calmodulin affects the binding of said polypeptide to an antigen to be bound by said polypeptide. The calmodulin may be a permutated calmodulin. A method for affecting the binding of a polypeptide for an antigen using said composition is also disclosed.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.