Methods for detecting or quantifying CTP and CTP synthase activity
US10731197B2 · kind B2 · utility
0Cited by
0References
19Claims
0Family size
Assignees
Inventors
Key dates
| Filing date | Oct 10, 2016 |
| Grant date | Aug 4, 2020 |
| Priority date | — |
| Expiry date | Apr 18, 2037 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/10
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention relates to a method for detecting or quantifying CTP in a cell sample comprising at least two nucleotide triphosphates by cationic ion pairing chromatography coupled to mass spectrometry, to a method for detecting or quantifying CTP synthase activity based on the method for detecting or quantifying CTP, and to their use in methods for screening potential immunosuppressive or anti-cancer compounds and in methods for determining the appropriate dose of an immunosuppressive or anti-cancer compound inhibiting CTP synthase activity for a treated subject.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.