Nanocrystals, compositions, and methods that aid particle transport in mucus

US10736854B2 · kind B2 · utility

Assignee

• THE JOHNS HOPKINS UNIVERSITY · US

Inventors

• Alexey Popov · Moscow, RU
• Elizabeth M. Enlow · Waltham, US
• James Bourassa · Somerville, US
• Colin R. Gardner · Lawrence, US
• Hongming Chen · Belmont, US
• Laura Ensign · Baltimore, US
• Samuel K. Lai · Carrboro, US
• Tao Yu · Shanghai, CN
• Justin Hanes · Baltimore, US
• Ming Yang · Towson, US

Key dates

• Filing date: May 10, 2018
• Grant date: Aug 11, 2020
• Expiry date: May 10, 2038

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K49/0089
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Nanocrystals, compositions, and methods that aid particle transport in mucus are provided. In some embodiments, the compositions and methods involve making mucus-penetrating particles (MPP) without any polymeric carriers, or with minimal use of polymeric carriers. The compositions and methods may include, in some embodiments, modifying the surface coatings of particles formed of pharmaceutical agents that have a low water solubility. Such methods and compositions can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for administration routes involving the particles passing through a mucosal barrier.