Triazole furan compounds as agonists of the APJ receptor

US10736883B2 · kind B2 · utility

Assignee

• AMGEN INC. · US

Inventors

• Matthew Brown · Fairfield, US
• Ning Chen · Thousand Oaks, US
• Xiaoqi Chen · Palo Alto, US
• Yinhong Chen · Hayward, US
• Alan C. Cheng · Cambridge, US
• Richard V. Connors · Mesa, US
• Jeffrey Deignan · San Francisco, US
• Paul John Dransfield · Arlington, US
• Xiaohui Du · Foster City, US
• Zice Fu · Foster City, US
• James S. Harvey · Arlington, US
• Julie Anne Heath · Chico, US
• Lars V. Heumann · Redwood City, US
• Jonathan Houze · Cambridge, US
• Frank Kayser · San Francisco, US
• Aarif Yusuf Khakoo · Woodside, US
• David John Kopecky · West Hollywood, US
• Su-Jen Lai · Somerville, US
• Zhihua Ma · Lexington, US
• Julio C. Medina · Redwood City, US
• Jeffrey T. Mihalic · San Francisco, US
• Steven H. Olson · Millbrae, US
• Vatee Pattaropong · Bedford, US
• Gayathri Swaminath · Brisbane, US
• Xiaodong Wang · Zhejiang, CN
• Malgorzata Wanska · Camarillo, US
• Wen-Chen YEH · Belmont, US

Key dates

• Filing date: Nov 3, 2017
• Grant date: Aug 11, 2020
• Expiry date: Nov 3, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F7/0812
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of Formula (I) and Formula (II), pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and have use in treating cardiovascular and other conditions. Compounds of Formula (I) and Formula (II) have the following structures: (I); (II). Intermediates (V) are also claimed.