Scaffolds and multifunctional intermediates for imaging PSMA and cancer therapy

US10736974B2 · kind B2 · utility

Assignee

• THE JOHNS HOPKINS UNIVERSITY · US

Inventors

• Martin G. Pomper · Baltimore, US
• Ronnie C. Mease · Fairfax, US
• Sangeeta Ray · Ellicott City, US
• Ying Chen · Timonium, US
• Xing Yang · Baltimore, US

Key dates

• Filing date: Oct 22, 2015
• Grant date: Aug 11, 2020
• Expiry date: Oct 22, 2035

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K49/0019
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Carbamate and beta-amino acid urea-based scaffolds that have high binding affinity to PSMA are disclosed. These scaffolds can be radiolabeled and used for imaging cells and tumors that express PSMA or for cancer radiotherapy. These compounds also can comprise a fluorescent dye and be used for imaging cells and tumors that express PSMA or for photodynamic therapy.