Non-gelling soluble extracellular matrix with biological activity

US10736991B2 · kind B2 · utility

Assignees

• University of Pittsburgh—Of the Commonwealth System of Higher Education · US
• The University of Nottingham · GB

Inventors

• Stephen F. Badylak · Lafayette, US
• Timothy Joseph Keane, Jr. · Brookfield, US
• Lisa Jane White · Nottingham, GB

Key dates

• Filing date: Sep 16, 2016
• Grant date: Aug 11, 2020
• Expiry date: Sep 16, 2036

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61L2420/02
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

Provided are methods for preparing non-gelling, solubilized extracellular matrix (ECM) materials useful as cell growth substrates. Also provided are compositions prepared according to the methods as well as uses for the compositions. In one embodiment a device, such as a prosthesis, is provided which comprises an inorganic matrix into which the non-gelling, solubilized ECM composition is dispersed to facilitate in-growth of cells into the ECM and thus adaptation and/or attachment of the device to a patient. In another embodiment, the composition is delivered intraarticularly, intrathecally, intraoccularly, intracranially, and into pleural space.