Method for constructing nitric oxide-generating adherent coating

US10736996B2 · kind B2 · utility

Assignees

• Chengdu Southwest Jiaotong University Science and · CN
• Chengdu Jiaoda Medical Science And Technology Comp · CN

Inventors

• Zhilu YANG · Sichuan, CN
• Nan Huang · Sichuan, CN
• Jin Wang · Sugar Land, US
• Yajun Weng · Sichuan, CN

Key dates

• Filing date: Aug 12, 2015
• Grant date: Aug 11, 2020
• Expiry date: Sep 2, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C08K5/13
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed is a method for preparing a nitric oxide-generating adherent coating, comprising: preparing a buffer solution containing polyphenol compounds, organic selenium or sulfur compounds and soluble copper salts; then contacting a base material with the solution, and washing and drying to obtain a target product. The nitric oxide-generating material prepared by the method can be used for any medical device, such as an intravascular stent, or materials and any complex-shaped base material, and has the capability of scavenging free radicals and catalyzing RSNO to produce nitrogen monoxide, and also has a response function of reduced glutathione (GSH), an antimicrobial function and all the physiological functions possessed by nitrogen monoxide.