Method of manufacturing 4-chloro-7H-pyrrolo[2,3-D]pyrimidine
US10738058B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Aug 11, 2017 |
| Grant date | Aug 11, 2020 |
| Priority date | — |
| Expiry date | Aug 11, 2037 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01D9/005
- WIPO fieldChemical engineering
- WIPO sectorChemistry
Abstract
The present invention discloses a method of manufacturing 4-chloro-7H-pyrrolo[2,3-d]pyrimidine comprising the steps: a) Preparing ethyl 2-cyano-4,4-dimethoxybutanoate by coupling ethyl 2-cyanoacetate and 2-bromo-1,1-dimethoxyethane; b) Preparing 6-amino-5-(2,2-dimethoxyethyl)pyrimidin-4-ol by adding formamidine to ethyl 2-cyano-4,4-dimethoxybutanoate; c) Converting 6-amino-5-(2,2-dimethoxyethyl)pyrimidin-4-ol to 7H-pyrrolo[2,3-d]pyrimidin-4-ol; and d) Converting the 7H-pyrrolo[2,3-d]pyrimidin-4-ol to 4-chloro-7H-pyrrolo[2,3-d]pyrimidine. The method offers increased yield, less by-products and a decrease in waste compared to methods known as being state of the art.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.