6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-2-carboxamide compounds

US10738063B2 · kind B2 · utility

Assignee

• PFIZER INC. · US

Inventors

• Thomas Allen Chappie · Old Lyme, US
• Nandini Chaturbhai Patel · Newton, US
• Patrick Robert Verhoest · Newton, US
• Christopher John Helal · Mystic, US
• Simone Sciabola · Cambridge, US
• Erik Alphie LaChapelle · Uncasville, US
• Travis T. Wager · Brookline, US
• Matthew Merrill Hayward · Old Lyme, US

Key dates

• Filing date: May 31, 2019
• Grant date: Aug 11, 2020
• Expiry date: May 31, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D519/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention is directed to PDE4B inhibitors of Formula I: (I) or a pharmaceutically acceptable salt thereof, wherein the substituents R1, R2, R3, and R4 are as defined herein. The invention is also directed to pharmaceutical compositions comprising the compounds, methods of treatment using the compounds, and methods of preparing the compounds.