Humanized antibodies transmigrating the blood-brain barrier and uses thereof
US10738115B2 · kind B2 · utility
1Cited by
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14Claims
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Key dates
| Filing date | Jul 4, 2017 |
| Grant date | Aug 11, 2020 |
| Priority date | — |
| Expiry date | Jul 4, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to antibodies and fragments thereof derived by humanization of an existing antibody, and methods of making them. The humanized antibodies of the present invention show enhanced binding to the brain endothelial antigen, improved transmigration across the blood-brain barrier, and increased thermal stability relative to the parent non-humanized antibody.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.