T7 RNA polymerase variants
US10738286B2 · kind B2 · utility
2Cited by
145References
22Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 19, 2018 |
| Grant date | Aug 11, 2020 |
| Priority date | — |
| Expiry date | Jul 14, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N15/00
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention provides engineered RNA polymerase variants and compositions comprising these variants. The present invention further provides engineered T7 RNA polymerase variants and compositions comprising these variants. These variants have been evolved for selective incorporation of the m7G(5′)ppp(5′)m7G cap analog over GTP at the initiation of in vitro transcription. The present invention also provides methods for selective capping of RNA transcripts.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.