Patent · US Active

Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses

US10738358B2 · kind B2 · utility

3Cited by

135References

9Claims

0Family size

Assignee

Sequenom, Inc. · US

Inventors

Mathias Ehrich · San Diego, US
Anders Olof Herman Nygren · San Diego, US

Key dates

Filing date	Jun 10, 2015
Grant date	Aug 11, 2020
Priority date	—
Expiry date	Mar 18, 2036

Classification

Technology area (CPC G)Physics
CPC primaryG01N2800/385
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

Provided are compositions and processes that utilize genomic regions differentially methylated between a mother and her fetus to separate, isolate or enrich fetal nucleic acid from a maternal sample. The compositions and processes described herein are useful for non-invasive prenatal diagnostics, including the detection of chromosomal aneuploidies.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.