Nanopore well structures and methods

US10739299B2 · kind B2 · utility

Assignee

• Roche Sequencing Solutions, Inc. · US

Inventors

• Ronald L. Cicero · Palo Alto, US
• Kenneth Honer · Santa Clara, US
• John Foster · Mountain View, US
• Pirooz Parvarandeh · Los Altos Hills, US
• Marowen Ng · San Jose, US
• Wing Kei Au · San Jose, US
• Guojun Chen · Madison, US

Key dates

• Filing date: Mar 13, 2018
• Grant date: Aug 11, 2020
• Expiry date: Nov 1, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2565/631
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A nanopore cell may include a well having a working electrode at a bottom of the well. The well may be formed within a dielectric layer, where the sidewalls of the well may be formed of the dielectric or other materials coating the walls of the dielectric layer. Various materials having different hydrophobicity and hydrophilicity can be used to provide desired properties of the cell. The nanopore in the nanopore cell can be inserted in a membrane formed over the well. Various techniques can be used for providing a desired shape and other properties e.g., of materials and processes for forming the well.