Edible oral strip or wafer dosage form containing ion exchange resin for taste masking

US10744176B2 · kind B2 · utility

Assignee

• LTS Lohmann Therapie-Systeme AG · DE

Inventors

• Michael Li · Hillsborough Township, US
• Markus Krumme · Neuwied, DE

Key dates

• Filing date: Jul 15, 2019
• Grant date: Aug 18, 2020
• Expiry date: Jul 15, 2039

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B29L2007/007
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

An edible orally disintegrating tablet dosage form containing an unpalatable acidic active pharmaceutical ingredient, particularly ketoprofen, and an ion exchange resin as a primary taste masking agent, along with an optional alkaline agent and further optionally containing one or more secondary taste masking agents is provided. The edible orally disintegrating tablet dosage matrix is formed from at least one water soluble or miscible polymer(s). The optional secondary taste masking ingredients include one or more of flavoring agent(s), sweetener(s), cooling sensation agent(s), and taste receptor blocker(s). The inventive dosages minimize or completely mask the bitterness, burning sensation and throat irritation associated with many acidic active pharmaceutical ingredients. Methods for preparing the inventive edible oral film strip dosage forms are disclosed, as well as their method of administration.