Methods of using variants of FGF19 polypeptides for the treatment of pruritus
US10744185B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 8, 2016 |
| Grant date | Aug 18, 2020 |
| Priority date | — |
| Expiry date | Feb 25, 2037 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/575
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided herein are variants of fibroblast growth factor 19 (FGF19) proteins and peptide sequences (and peptidomimetics) and fusions of FGF19 and/or fibroblast growth factor 21 (FGF21) proteins and peptide sequences (and peptidomimetics), and variants of fusions of FG-F19 and/or FGF21 proteins and peptide sequences (and peptidomimetics). In some embodiments, these variants and fusions modulate bile acid homeostasis, and are useful in treatment of bile acid related and associated disorders. In some embodiments, these variants and fusions have glucose lowering activity, and are useful in treatment of hyperglycemia and other disorders.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.