Pyridine derivatives and their use in the treatment of cancer and hemoglobinopathies
US10745380B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Mar 9, 2017 |
| Grant date | Aug 18, 2020 |
| Priority date | — |
| Expiry date | Aug 11, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D213/82
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A compound of formula (Ia), (Ib) or (Ic) wherein: n is 1 or 2; RN is H or Me; R1 is optionally one or more halo or methyl groups; R2a and R2b are independently selected from the group consisting of: (i) F; (ii) H; (iii) Me; and (iv) CH2OH; R2c and R2d (if present) are independently selected from the group consisting of: (i) F; (ii) H; (iii) Me; and (iv) CH2OH; R3a and R3b are independently selected from H and Me; R4a is selected from OH, —NH2, —C(═O)NH2, and —CH2OH; R4b is either H or Me; R5 is either H or Me; A is either (i), where R6a is ether; or (ii), where X is selected from CH2, NH and O, one of R7a and R7b is selected from CI and ethoxy and the other of R7a and R7b is H.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.