Patent · US Active

1-Substituted 1,2,3,4-tetrahydro-1,7-naphthyridin-8-amine derivatives and their use as EP4 receptor antagonists

US10745397B2 · kind B2 · utility

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5Claims

0Family size

Assignee

Takeda Pharmaceutical Company Limited · JP

Inventors

Dinesh Barawkar · Lake Forest, US
Anil Deshpande · Jamkhed, IN
Santosh K. Patil · Pune, IN
Yogesh Waman · Pune, IN
Anil Panmand · Pimpri-Chinchwad, IN
Dilip Jadhav · Mumbai, IN
Bheemashankar A. Kulkarni · Noida, IN

Key dates

Filing date	Jul 26, 2016
Grant date	Aug 18, 2020
Priority date	—
Expiry date	Jul 26, 2036

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D513/04
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The present invention provides a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof has an EP4 receptor antagonistic action, and is useful as an agent for the prophylaxis or treatment of EP4 receptor associated diseases (e.g., rheumatoid arthritis, aortic aneurysm (e.g. abdominal aortic aneurysm, thoracic aortic aneurysm, thoracoabdominal aortic aneurysm etc.), endometriosis, ankylosing spondylitis, inflammatory breast cancer etc.) and the like.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.