Conjugates that are configured for targeted delivery of therapeutic compounds to senescent cells
US10745445B2 · kind B2 · utility
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23References
14Claims
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Key dates
| Filing date | Mar 27, 2018 |
| Grant date | Aug 18, 2020 |
| Priority date | — |
| Expiry date | Jul 6, 2038 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/50
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed are agents (e.g., peptides, polypeptides, proteins, small molecules, antibodies, and antibody fragments that target senescent cells) and methods of their use for imaging senescent cells in vivo and for treating or preventing cancer, age-related disease, tobacco-related disease, or other diseases and disorders related to or caused by cellular senescence in a mammal. The methods include administering one or more of the agents of the invention to a mammal, e.g., a human. The agents, which specifically bind to senescent cells, can be labeled with a radioactive label or a therapeutic label, e.g., a cytotoxic agent.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.