Compositions and methods for enhancing visual function

US10745453B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Ehud Y. Isacoff · Berkeley, US
• Michael H. Berry · Berkeley, US
• Amy Beth Holt · Aberdeen, GB
• Meike Visel · Corona, US
• Autoosa Salari · Berkeley, US
• John G. Flannery · Berkeley, US
• Benjamin M. Gaub · Berkeley, US

Key dates

• Filing date: Feb 19, 2019
• Grant date: Aug 18, 2020
• Expiry date: Feb 19, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2750/14143
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure provides a method of restoring or enhancing visual function in an individual, the method comprising administering to the individual a nucleic acid comprising a nucleotide sequence encoding one or more of a medium wavelength cone opsin (MW-opsin), a long wavelength cone opsin (LW-opsin), and a short wavelength cone opsin (SW-opsin). One or more of the MW-opsin, LW-opsin, and SW-opsin is expressed in a retinal cell in the individual, thereby restoring or enhancing visual function.