TAL-effector assembly platform, customized services, kits and assays

US10745695B2 · kind B2 · utility

Assignees

• Life Technologies Corporation · US
• THERMO FISHER SCIENTIFIC GENEART GMBH · DE

Inventors

• Jonathan Chestnut · Carlsbad, US
• Matthias Arnold · Zolling, DE
• Kevin Hoff · San Diego, US

Key dates

• Filing date: Apr 12, 2018
• Grant date: Aug 18, 2020
• Expiry date: Apr 12, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Y599/01002
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The invention generally relates to compositions and methods for designing and producing functional DNA binding effector molecules and associated customized services, tool kits and functional assays. In some aspects, the invention provides methods and tools for efficient assembly of customized TAL effector molecules. Furthermore, the invention relates to uses of TAL effector molecules and functional evaluation of such TAL by, for example, customized assays.