Patent · US Active

Specific nucleic acid amplification with compounded selectivity

US10745746B2 · kind B2 · utility

2Cited by

4References

12Claims

0Family size

Assignee

President and Fellows of Harvard College · US

Inventors

Xi Chen · Newton, US
David Zhang · Elmont, US
Peng Yin · Ithaca, US

Key dates

Filing date	Jul 18, 2014
Grant date	Aug 18, 2020
Priority date	—
Expiry date	Jul 9, 2036

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12Q1/6848
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The present disclosure provides, in various aspects and embodiments, methods and compositions for selectively amplifying a rare target nucleic acid and/or suppressing amplification of non-target nucleic acids with sequences similar to the rare target nucleic acid. The methods and composition are useful, for example, for detecting rare alleles among a population of wild-type alleles.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.