Apparatuses, systems and methods for sequencing using capillary electrophoresis

US10746695B2 · kind B2 · utility

Assignee

• Life Technologies Corporation · US

Inventors

• Ian Walton · Redwood City, US
• Robert Cobene · Santa Clara, US
• Alexander V. Dukhovny · San Francisco, US
• Adam Sannicandro · San Francisco, US
• John Dixon · Moss Beach, US
• Achim Karger · Foster City, US
• Dan Kline · Vista, US

Key dates

• Filing date: Mar 6, 2015
• Grant date: Aug 18, 2020
• Expiry date: Mar 6, 2035

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N35/10
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

In one aspect, a biological sequencing device comprising a cartridge configured to be removed from the instrument is disclosed. In various embodiments the cartridge can include one or more capillaries suitable for capillary electrophoresis, a reservoir and a pump. In various embodiments the reservoir can contain a separation matrix. In various embodiments the pump can load a capillary with separation matrix. In another aspect the biological sequencing device can include one or more capillaries and an integrated valve assembly. In various embodiments the integrated valve assembly can provide a polymer to the one or more capillaries.