Systems and methods for ex vivo lung care

US10750738B2 · kind B2 · utility

Assignee

• TRANSMEDICS, INC. · US

Inventors

• Robert Fishman · Boston, US
• Robert Havener · Lynnfield, US
• Ihab Abdel Fattah · Andover, US
• Anas Abdelazim · North Andover, US
• Scott W. Newell · Ipswich, US
• Thomas H. Bishop · Wenham, US
• Tamer I. KHAYAL · North Andover, US
• Stanley Kyi · Andover, US
• Ron Taylor · Pleasanton, US
• Doug Harriott · Melrose, US
• Matthew De Remer · Brookline, US
• Paul Murray · Groton, US
• John Sullivan · Land O' Lakes, US
• Mark Anderson · Danvers, US
• Richard Bringham · North Andover, US
• Michael R. Van Driel · Willow View Lane, US
• Waleed H. HASSANEIN · North Andover, US

Key dates

• Filing date: Apr 8, 2008
• Grant date: Aug 25, 2020
• Expiry date: May 6, 2030

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A01N1/143
• WIPO field: Basic materials chemistry
• WIPO sector: Chemistry

Abstract

Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.