Patent · US Active

Targeted therapy to deplete tumor-associated macrophages (TAMs)

US10751284B1 · kind B1 · utility

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11Claims
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Assignee

Inventors

Key dates

Filing dateAug 15, 2017
Grant dateAug 25, 2020
Priority date—
Expiry dateAug 15, 2037

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC07K2317/55
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

Provided herein are tumor associated macrophage (TAM)-targeting liposome having a lipid bilayer; a targeting agent associated with the lipid bilayer, wherein the targeting agent comprises an antibody or fragment thereof that selectively binds a tumor associated macrophage; and a cytotoxic agent associated with the lipid bilayer, wherein the cytotoxic agent depletes tumor associated macrophages at or near the site of a tumor. Also provided are pharmaceutical compositions comprising the TAM-targeting liposomes and methods of treating a subject with cancer with the compositions.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.