Polymorphic and amorphous forms of (R)-2-hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dienyl)butanamide

US10751302B2 · kind B2 · utility

Assignee

• PTC THERAPEUTICS, INC. · US

Inventors

• Paul Mollard · Domène, FR
• Peter Giannousis · Mountain View, US
• Shazad Suchit · Devens, US
• Mahmoud Mirmehrabi · Halifax, CA

Key dates

• Filing date: Mar 14, 2019
• Grant date: Aug 25, 2020
• Expiry date: Mar 14, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/16
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed herein are polymorphic and amorphous forms of anhydrate, hydrate, and solvates of (R)-2-hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dienyl)butanamide and methods of using such compositions for treating or suppressing oxidative stress disorders, including mitochondrial disorders, impaired energy processing disorders, neurodegenerative diseases and diseases of aging. Further disclosed are methods of making such polymorphic and amorphous forms.