Carbon monoxide-releasing molecules for therapeutic applications and methods for the preparation and use thereof

US10751344B2 · kind B2 · utility

Assignee

• Georgia State University Research Foundation · US

Inventors

• Binghe Wang · Marietta, US
• Danzhu Wang · Atlanta, US
• Xingyue Ji · Atlanta, US
• Alexander Draganov · Atlanta, US
• Chaofeng Dai · Wilmington, US
• Krishna Damera · Smyrna, US
• Didier Merlin · Decatur, US
• Emilie Viennois · Atlanta, US
• Yueqin Zheng · Atlanta, US

Key dates

• Filing date: May 27, 2019
• Grant date: Aug 25, 2020
• Expiry date: May 27, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B37/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Carbon monoxide-releasing organic molecules are described herein. The molecules can be synthesized prior to administration (e.g., ex vivo) or formed in vivo. In those embodiments where the molecules are formed in vivo, reactants are administered under physiological conditions and undergo a cycloaddition reaction to form a product which releases carbon monoxide. In applying such reactions for therapeutic applications in vivo, the cycloaddition and CO release typically occur only under near-physiological or physiological conditions. For example, in some embodiments, the cycloaddition reaction and/or release of carbon monoxide occur at a temperature of about 37° C. and pH of about 7.4. Pharmaceutical compositions and methods for release carbon monoxide are also described.