Regulation of autonomic control of bladder voiding after a complete spinal cord injury

US10751533B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Victor Reggie Edgerton · Los Angeles, US
• Parag Gad · Calabasas, US
• Roland R. Roy · Culver City, US
• Yury Gerasimenko · Los Angeles, US
• Daniel C. Lu · Los Angeles, US
• Hui Zhong · 红钢城街道, CN

Key dates

• Filing date: Aug 21, 2015
• Grant date: Aug 25, 2020
• Expiry date: Feb 13, 2036

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61N1/36175
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

In various embodiments methods and devices are provided for regulating bladder function in a subject after a spinal cord and/or brain injury. In certain embodiments the methods comprise applying a pattern of electrical stimulation to the Lumbosacral spinal cord at a frequency and intensity sufficient to initiate micturition and/or to improve the amount of bladder emptying. In certain embodiments the electrical stimulation is at a frequency and intensity sufficient to improve the amount of bladder emptying (e.g., to provide at least 30% emptying or at least 40% emptying, or at least 50% emptying, or at least 60% emptying, or at least 70% emptying, or at least 80% emptying, or at least 90% emptying, or at least 95% emptying.