Diamide macrocycles having factor XIa inhibiting activity
US10752641B2 · kind B2 · utility
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10Claims
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Key dates
| Filing date | Mar 1, 2017 |
| Grant date | Aug 25, 2020 |
| Priority date | — |
| Expiry date | Mar 1, 2037 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P9/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective Factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.