April variants
US10752665B2 · kind B2 · utility
1Cited by
3References
34Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 26, 2015 |
| Grant date | Aug 25, 2020 |
| Priority date | — |
| Expiry date | May 29, 2035 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/22
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides a variant proliferation-inducing ligand (APRIL) which has a higher binding affinity to BCMA than wild-type APRIL; and/or altered binding kinetics compared with wild-type APRIL, and/or a higher BCMA:TACI (transmembrane activator and calcium modulator and cyclophilin ligand interactor) binding ratio than wild-type APRIL and which comprises mutations at one or more of the following positions: A125, V174, T175, M200, P201, S202, H203, D205 and R206.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.