Lentiviral vectors for regulated expression of a chimeric antigen receptor molecule

US10752668B2 · kind B2 · utility

Assignees

• THERAVECTYS · FR
• INSTITUT CURIE · FR
• CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE · FR
• Sorbonne Universite · FR
• Institut National de la Sante et de la Recherche Medicale (INSERM) · FR

Inventors

• Sophie AGAUGUE · Paris, FR
• Lorenzo TIBALDI · Paris, FR
• Klervi EVEN-DESRUMAUX · Antony, FR
• Dmitry TRUBETSKOY · Arcueil, FR
• Franck Perez · Paris, FR
• Sebastian AMIGORENA · Paris, FR
• Cecile Bauche · Paris, FR

Key dates

• Filing date: Jul 24, 2015
• Grant date: Aug 25, 2020
• Expiry date: Jul 24, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2799/027
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to the regulated expression of a chimeric antigen receptor (CAR) within a lentiviral vector. The CAR comprises a hook-binding domain that interacts with a hook, preferably encoded by the same lentiviral vector, which prevents proper processing and release of the CAR to the cell membrane. The invention encompasses vectors, methods of making the vectors, and methods of using them, including medicinal uses. The vectors can be used for administration to humans to induce immune responses and to treat cancers and tumors.