Single-stranded oligonucleotide probes for chromosome or gene copy enumeration

US10752955B2 · kind B2 · utility

Assignee

• Ventana Medical Systems, Inc. · US

Inventors

• Michael Farrell · Tucson, US
• Antony Hubbard · Tucson, US
• Donald Johnson · Brookline, US
• Brian D. Kelly · Orlando, US
• Taylor Shingler · Tucson, US
• Lei Tang · Zhenjiang, CN
• Wenjun Zhang · Sha Tin, CN

Key dates

• Filing date: Aug 19, 2016
• Grant date: Aug 25, 2020
• Expiry date: Dec 10, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2600/158
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Single-stranded oligonucleotide probes, systems, kits and methods for chromosome enumeration, gene copy enumeration, or tissue diagnostics. The probes are particularly suited for detecting gene amplification, deletion, or rearrangement in tissue samples in a single, dual, or multiplexed assay. The probes exhibit improved performance compared to industry leading dual-stranded probes; particularly in terms of the rate of hybridization.