Biocompatible nanoparticles with aggregation induced emission characteristics as fluorescent bioprobes and methods of using the same for in vitro and in vivo imaging

US10753941B2 · kind B2 · utility

Assignees

• The Hong Kong University of Science and Technology
• NATIONAL UNIVERSITY OF SINGAPORE · SG

Inventors

• Benzhong Tang · Hong Kong, CN
• Wei Qin · Beijing, CN
• Jianzhao Liu · Hong Kong, CN
• Sijie Chen · Hong Kong, CN
• Tsz Kin Kwok · Hong Kong, CN
• Bin Liu · Fishers, US
• Kai Li · Princeton, US
• Dan Ding · Hong Kong, CN
• Haibin Shi · Singapore, SG
• Jun Geng · Beijing, CN
• Jingzhi Sun · Hangzhou City, CN
• Anjun Qin · Zhejiang, CN
• Qiuli Zhao · Zhejiang, CN

Key dates

• Filing date: Sep 3, 2012
• Grant date: Aug 25, 2020
• Expiry date: Oct 4, 2035

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2333/96466
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The development of fluorescent bioprobes comprising organic fluorescent compounds that exhibit aggregation induced emission (AIE) properties, methods of producing the same, and their practical applications for in vitro and in vivo bioimaging.