Method for aiding differential diagnosis of stroke
US10753948B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jun 4, 2014 |
| Grant date | Aug 25, 2020 |
| Priority date | — |
| Expiry date | Jun 4, 2034 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/2871
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention provides a method of aiding the differential diagnosis of haemorrhagic stroke, ischemic stroke and a transient ischemic attack in a patient who has suffered or is suffering a stroke. The method comprises: (i) determining the concentration of the biomarkers VCAM-1, GFAP and CRP in an ex vivo sample obtained from the patient; and (ii) establishing the statistical significance of the concentration of the biomarkers. Optionally, the method further comprises steps of (iii) determining the concentration of the biomarkers IL-6 and sTNFR1 in an ex vivo sample obtained from the patient; (iv) determining the gender of the patient; and (v) establishing the statistical significance of the concentration of the five biomarkers, in conjunction with the patient's gender. The present invention also provides substrates comprising probes for VCAM-1, GFAP and CRP for use in a method for aiding the differential diagnosis of stroke.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.