Combination therapies using anti-metabolites and agents that target tumor-associated stroma or tumor cells

US10758613B2 · kind B2 · utility

Assignees

• THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES, OFFICE OF TECHNOLOGY TRANSFER—NATIONAL INSTITUTES OF HEALTH · US
• Biomed Valley Discoveries, Inc. · US

Inventors

• Saurabh Saha · Wellesley, US
• Xiaoyan Zhang · Lexington, US
• Dimiter S. Dimitrov · Frederick, US
• Zhongyu Zhu · Frederick, US
• Brad St. Croix · Frederick, US
• Enrique Zudaire · Germantown, US

Key dates

• Filing date: Jun 9, 2015
• Grant date: Sep 1, 2020
• Expiry date: Oct 17, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/94
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides, inter alia, methods for treating or ameliorating the effects of a disease, such as cancer, in a subject. The methods include: administering to a subject in need thereof (a) a therapeutically effective amount of an agent selected from an anti-metabolite agent or analog thereof and combinations thereof; and (b) a therapeutically effective amount of a monoclonal antibody or antigen binding fragment thereof, wherein the monoclonal antibody contains: (i) a heavy chain variable region (VH), which includes an amino acid sequence selected from SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:5, and SEQ ID NO:7; and (ii) a light chain variable region (VL), which includes an amino acid sequence selected from SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO:6, and SEQ ID NO:8. Compositions, including pharmaceutical compositions, and kits for treating diseases, such as cancer, are also provided herein.