Pharmaceutically active agent complexes, polymer complexes, and compositions and methods involving the same

US10758623B2 · kind B2 · utility

Assignee

• Durect Corporation · US

Inventors

• Michael Sekar · Palo Alto, US
• Felix Theeuwes · Los Altos, US
• Keith E. BRANHAM · Pelham, US
• John W. Gibson · Springville, US
• James Matriano · Mountain View, US
• Whitney Moro · Birmingham, US
• John Tipton · Leeds, US
• William Van Osdol · Mountain View, US
• Su Il Yum · Los Altos, US

Key dates

• Filing date: Feb 2, 2018
• Grant date: Sep 1, 2020
• Expiry date: Apr 29, 2038

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure generally provides complexes including a pharmaceutically active agent and a functionalized polymer, wherein the functionalized polymer includes repeat units, the repeat units including ionizable repeat units having at least one ionizable side group and/or ionizable end group, a plurality of the at least one ionizable groups forming non-covalent bonds with the pharmaceutically active agent. Polymers which may be used to form such complexes as well as methods of making and using the complexes and related compositions are also provided.