2-phenyl-3-(piperazinomethyl)imidazo[1,2-A]pyridine derivatives as blockers of task-1 and task-2 channels, for the treatment of sleep-related breathing disorders

US10759794B2 · kind B2 · utility

Assignee

• Bayer Pharma Aktiengesellschaft · DE

Inventors

• Martina Delbeck · Essen, DE
• Michael Hahn · Langenfeld, DE
• Thomas Müller · Bonn, DE
• Heinrich Meier · Wuppertal, DE
• Klemens Lustig · Wuppertal, DE
• Johanna Mosig · Dortmund, DE
• Luisella Toschi · Berlin, DE
• Udo Albus · Florstadt, DE
• Doris Gehring · Kelkheim, DE
• Björn Rosenstein · Salmünster, DE

Key dates

• Filing date: Dec 7, 2016
• Grant date: Sep 1, 2020
• Expiry date: Dec 7, 2036

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P11/16
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present application relates to novel 2-phenyl-3-(piperazinomethyl)imidazo[1,2-a]pyridine derivatives, to processes for their preparation, to their use alone or in combinations for the treatment and/or prevention of diseases, and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for treatment and/or prevention of respiratory disorders including, sleep-related respiratory disorders such as obstructive sleep apnoeas and central sleep apnoeas and snoring.