Compounds and their use as inhibitors of N-myristoyl transferase

US10759804B2 · kind B2 · utility

Assignee

• Imperial College Innovations Ltd · GB

Inventors

• Andrew Simon Bell · London, GB
• Edward William Tate · London, GB
• Robin John Leatherbarrow · London, GB
• Jennie Ann Hutton · London, GB
• James Antony Brannigan · York, GB

Key dates

• Filing date: Jun 29, 2016
• Grant date: Sep 1, 2020
• Expiry date: Jun 29, 2036

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This invention provides compounds of formula (I) and salts thereof, which have activity as inhibitors of N-myristoyl transferase (NMT). The invention also relates to uses of such compounds as medicaments, in particular in the treatment of a disease or disorder in which inhibition of N-myristoyl transferase provides a therapeutic or prophylactic effect, including protozoan infections (such as malaria and leishmaniasis), viral infections (such as human rhinovirus and HIV), and hyperproliferative disorders (such as B-cell lymphoma).