Monofunctional intermediates for ligand-dependent target protein degradation

US10759808B2 · kind B2 · utility

Assignee

• THE REGENTS OF THE UNIVERSITY OF MICHIGAN · US

Inventors

• Shaomeng Wang · Saline, US
• Yangbing Li · Beijing, CN
• Angelo Aguilar · Ann Arbor, US
• Bing Zhou · Ann Arbor, US
• Jiantao Hu · Ann Arbor, US
• Fuming Xu · Ypsilanti, US
• Chong Qin · Ann Arbor, US
• Yang Hu · Brookline, US
• Weiguo Xiang · Ypsilanti, US
• Rohan Rej · Ann Arbor, US
• Jiuling Yang · Ann Arbor, US
• Xin Han · Ann Arbor, US
• Longchuan Bai · Ann Arbor, US
• Chao-Yie Yang · Hangzhou City, CN

Key dates

• Filing date: Apr 6, 2017
• Grant date: Sep 1, 2020
• Expiry date: Apr 6, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D495/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present disclosure provides compounds represented by Formula I: and the salts or solvates thereof, wherein X, L, Y, and B are as defined in the specification. Compounds having Formula I are immunomodulators and/or monofunctional synthetic intermediates that can be used to prepare small-molecule drug conjugates.