Klebsiella pneumoniae O3 specific antibodies

US10759848B2 · kind B2 · utility

Assignees

• ARSANIS Biosciences GmbH · AT
• Max-Planck-Gesellschaft zur Föderung der Wissenschaften e.V. · US

Inventors

• Valeria SZIJARTO · Wien, AT
• Gabor Nagy · Redmond, US
• Luis GUACHALLA · Wien, AT
• Katharina RAMONI · Wien, AT
• Adriana BADARAU · Wien, AT
• Eszter Nagy · Wien, AT
• Tim ROLLENSKE · Heidelberg, DE
• Hedda WARDEMANN · Heidelberg, DE
• Irina MIRKINA · Wien, AT

Key dates

• Filing date: Aug 11, 2017
• Grant date: Sep 1, 2020
• Expiry date: Aug 11, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/92
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A cross-neutralizing monoclonal antibody that specifically recognizes a cross-reactive epitope of the lipopolysaccharide (LPS) antigen structure of Klebsiella pneumoniae, which is an O3b epitope, cross-reacting with an O3a epitope and an O3 epitope, wherein the antibody is characterized by specific CDR sequences or VH and VL sequences.