Conditionally immortalized long-term stem cells and methods of making and using such cells

US10760055B2 · kind B2 · utility

Assignees

• National Jewish Health · US
• The Regents of the University of Colorado · US

Inventors

• John C. Cambier · Denver, US
• Yosef Refaeli · Denver, US
• Sara Ann Johnson · Cambridge, US
• Brian Curtis Turner · Denver, US

Key dates

• Filing date: Jul 23, 2018
• Grant date: Sep 1, 2020
• Expiry date: Jul 23, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2740/16322
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Disclosed are methods for conditionally immortalizing stem cells, including adult and embryonic stem cells, the cells produced by such methods, therapeutic and laboratory or research methods of using such cells, and methods to identify compounds related to cell differentiation and development or to treat diseases, using such cells. A mouse model of acute myeloid leukemia (AML) and cells and methods related to such mouse model are also described.