Tuning microbial populations with programmable nucleases
US10760065B2 · kind B2 · utility
18Cited by
2References
20Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 3, 2014 |
| Grant date | Sep 1, 2020 |
| Priority date | — |
| Expiry date | Sep 3, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N15/74
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Various aspects and embodiments of the invention are directed to methods and compositions for reversing antibiotic resistance or virulence in and/or destroying pathogenic microbial cells such as, for example, pathogenic bacterial cells. The methods include exposing microbial cells to a delivery vehicle with at least one nucleic acid encoding an engineered autonomously distributed circuit that contains a programmable nuclease targeted to one or multiple genes of interest.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.