Method and apparatus to diagnose the metastatic or progressive potential of cancer, fibrosis and other diseases

US10765376B2 · kind B2 · utility

Assignee

• University of Rochester · US

Inventors

• Edward Bernard Brown, III · Honeoye Falls, US
• Seth Warrington Perry · Pittsford, US
• Kathleen Anne Burke · Rockville Centre, US
• Robert Matthew Kottmann · Rochester, US
• Patricia Sime · Pittsford, US
• Jesse Sharp · Melbourne, AU

Key dates

• Filing date: Apr 7, 2015
• Grant date: Sep 8, 2020
• Expiry date: Sep 3, 2036

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N21/6486
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A method and apparatus for determining the progressive potential of a disease is disclosed. The forward to backward propagating second harmonic generation signal derived from a second harmonic generation instrument is used to assess the collagen microstructure of imaged body tissue by way of numerical values that are in turn used to determine the progressive or metastatic potential of the disease. The disease may, for example, be a cancer such as breast cancer, lung fibrosis, colorectal adenocarcinoma, or the like. The apparatus may include in vivo instruments or laboratory diagnostic instruments with methods disclosed herein.